Hypoxia Triggers TAZ Phosphorylation in Basal A Triple Negative Breast Cancer Cells.

Shared and Distinct Changes in Expression of YAP/TAZ/TEAD Target Genes in Response to Hypoxia in Luminal and Basal A Breast Cancer Cells The response of three known YAP/TAZ target genes (CYR61, AXL, CTGF) to hypoxia in two luminal and two basal A TNBC cell lines showed an overall trend of increased expression in hypoxia, with CTGF being significantly enhanced in basal A but not luminal cells ( Figure 2 E).

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