Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing.

Proc Natl Acad Sci U S A · 2022 · PMC9457326 · PMID 36037350

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highly significantno p-value reported

The research outlined in this manuscript is highly significant as it demonstrates the impact of “Thiomorpholinos” as a robust and cost-effective splice-switching ASO platform that can be tested for enhanced biological activity and reduced toxicity relative to other chemistries.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.