CAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies.

Nat Commun · 2022 · PMC9461447 · PMID 36085303

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

marginal significancep = 0.07so close (0.05 < p ≤ 0.1)

Two pathways (Phenylalanine, tyrosine and tryptophan biosynthesis; Riboflavin metabolism) reached marginal significance ( p = 0.07).

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almost significantlyno p-value reported

In NHL, Faecalibacterium , Bifidobacterium , and Ruminococcus were significantly (or almost significantly) enriched in CR versus PR and in patients not having a remission (NR), consistent with our results in myeloma (Supplementary Fig. 5e ).

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