Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity.

JCI Insight · 2022 · PMC9462486 · PMID 35797133

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The interaction of the BCKA/BCAA ratio with sex was marginally significant ( P = 0.05); sex-stratified analysis then revealed that BCKA/BCAA was associated with steatosis grade in female participants (OR [95% CI], 1.7 [1.2–2.3], P = 0.002), but the association was completely absent in the male cohort (OR [95% CI], 1.0 [0.7–1.5], P = 0.9) ( Supplemental Figure 1 ).

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