Rare genetic variant burden in DPYD predicts severe fluoropyrimidine-related toxicity risk.

Biomed Pharmacother · 2022 · PMC9463069 · PMID 36063648

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borderline significantno p-value reported

When considering the variants burden and the risk of developing severe fluoropyrimidine toxicity ( Table 3 A), a borderline significant association was observed for very rare variants (including novel ones).

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