In these cell types, there was an obvious trend toward lower NR4A3 expression levels in more immature cell populations (e.g., hematopoietic stem cells and multi-potent progenitors) compared to more differentiated populations (e.g., band cells, polymorphonuclear neutrophils, and monocytes) (Supplementary Fig. 1 ).
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Functional association of NR4A3 downregulation with impaired differentiation in myeloid leukemogenesis.
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