A highly significant increase of the the high-affinity component of D 2 R (D2R Ki High) values was found upon cotreatment with the mGluR 5 and A 2A R agonists in the cells expressing A 2A R, D 2 R and mGluR 5 with a significant effect observed also with the mGluR 5 agonist alone compared to cells expressing only D 2 R and mGluR 5 .
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The mGlu<sub>5</sub> Receptor Protomer-Mediated Dopamine D<sub>2</sub> Receptor Trans-Inhibition Is Dependent on the Adenosine A<sub>2A</sub> Receptor Protomer: Implications for Parkinson's Disease.
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