Acetaminophen-induced reduction of NIMA-related kinase 7 expression exacerbates acute liver injury.

Additionally, we profiled the transcriptome of liver tissue from iKO mice and Ctrl mice and found that the relative transcript levels of cyclin B1 and CDK1 in the iKO livers were decreased significantly compared with those in the control livers, with a decreasing trend in other cell cycle-related genes ( Fig. 5 A), and these results were validated by qRT-PCR ( Fig. 5 B).

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