Expediting the chromatographic analysis of COVID-19 antibody therapeutics with ultra-short columns, retention modeling and automated method development.

J Pharm Biomed Anal · 2022 · PMC9465490 · PMID 36115204

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a pronounced trendno p-value reported

RPLC analysis of casirivimab and imdevimab subunits There has been a pronounced trend in RPLC analysis of mAbs that favors a so-called middle-up approach, which consists of a separation of reduced light chain (LC) and heavy chain (HC) variants or the analysis of Fc, sFc, Fab, F(ab’) 2 or Fd’ fragments that can be created by limited proteolysis [31] .

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