Barely Significant
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Premature aging is associated with higher levels of 8-oxoguanine and increased DNA damage in the Polg mutator mouse.

Aging Cell · 2022 · PMC9470903 · PMID 35993394

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an overall trendno p-value reported
However, while the results showed an overall trend that Polg mut/mut increases the 8‐oxodG levels in mtDNA of heart and liver, the difference was not statistically significant (Figure 5h,i ).

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