Iron-catalysed alkene and heteroarene H/D exchange by reversible protonation of iron-hydride intermediates.

It was observed that for the deuteration of styrene derivatives there was a slight trend for greater deuterium incorporation at the α position relative to both β positions, contrasting with results often seen with precious metal alternatives. 14 b ,15 b ,17 2,3-Dihydrofuran 4g underwent deuteration at both alkene C(sp 2 )–H bonds while the 6-membered 2,3-dihydropyran 4h was selectively deuterated at the 3-position.

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