Associations between locus coeruleus integrity and diagnosis, age, and cognitive performance in older adults with and without late-life depression: An exploratory study.

In support of this notion, in rodents, chronic and repeated stress results in increased LC norepinephrine ( Fan et al., 2014 ), and one LC-MRI study in humans report a statistical trend towards increased LC contrast in individuals with anxiety compared to healthy controls ( Morris et al., 2020 ).

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