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Impact of sociodemographic factors and screening, diagnosis, and treatment strategies on colorectal cancer mortality in Brazil: A 20-year ecological study.

PLoS One · 2022 · PMC9477339 · PMID 36107976

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an increasing trendno p-value reported
In this study, an increasing trend of mortality was observed in those aged > 45 years, with the risk increasing by 1.15% per year.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.