Significant correlations between LPC16:0 concentrations and pain (VAS) were observed ( P = 0.016 or P = 0.031 for VAS knee and VAS global, respectively, supplementary table 2, available at http://links.lww.com/PAIN/B579 ), and an inverse correlation with KOOS questionnaire almost reached statistical significance ( P = 0.060, supplementary table 2, available at http://links.lww.com/PAIN/B579 ).
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Lysophosphatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3.
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