Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer's Disease.

Next, we examined the 3, 6, and 9, months changes in the cortex using Western and found higher levels of levels of glial fibrillary acidic protein in 5XFAD male and female mice, culminating in a highly significant two-fold increase at month 9 (3 months: FC 5XFAD/WT = 1.19 and p -value = 0.34; 6 months: FC 5XFAD/WT = 1.46 and p -value = 0.091; 9 months: FC 5XFAD/WT = 1.97 and p -value ≤ 0.0001) ( Fig. 5 , A – C ).

also in 132,142 other papers