A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease.

After IMQ-induced psoriasis, the proportion of Th1 cells that secrete IFN-γ (CD3 + CD4 + IFN-γ + ) in the lymph nodes of K14-WFDC12 transgenic mice was higher than that of WT mice ( Figures 4A, B ) , whereas Th17 cells that secrete IL-17 (CD3 + CD4 + IL-17 + ) has no statistically significant differences between two IMQ-induced psoriasis groups ( Figures 4A, C ) , but compared with WT mice, the differentiation of Th17 cells in lymph nodes of K14-WFDC12 transgenic mice showed an overall trend of increase.

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* p < 0.05, the difference is statistically significant, ** p < 0.01, the difference is statistically very significant, *** p < 0.001, the difference is statistically extremely significant, and ns indicates no statistical significance.

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