Barely Significant
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Evaluation of the immunomodulatory effects of interleukin-10 on peripheral blood immune cells of COVID-19 patients: Implication for COVID-19 therapy.

Front Immunol · 2022 · PMC9486547 · PMID 36148228

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a decreasing trendno p-value reported
Although not significant, a decreasing trend was also observed in the frequency of IFN-γ + and IL-2 producing CD4 + T-cells ( Figures 7B , C ).

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an increasing trendno p-value reported
IL-10, GM-CSF, and IL-6 increased later and showed an increasing trend over time.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.