MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT.

Redox Biol · 2022 · PMC9486620 · PMID 36126419

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a decreasing trendno p-value reported

The MPST plasmid or mutated MPST (C248A) plasmid was transfected into MPST-knockdown HT29 cells, and the increased cytokines (TNF-α and ICAM) by MPST deficiency could be rescued by overexpression of MPST, showing a decreasing trend but no significant difference in the mutated MPST (C248A) plasmid in HT29 cells ( Fig.

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