Phytotherapeutic Approach in the Management of Cisplatin Induced Vomiting; Neurochemical Considerations in Pigeon Vomit Model.

Effect of Metoclopramide or Combination 4 on Neurotransmitters Cum Metabolites in the Brain Areas and Intestine at 18 th Hour of Cisplatin Treatment The concentration of neurotransmitter–Dopamine was significantly ( P < 0.001) increased in the area postrema while a nonsignificant trend was observed in the brain stem and intestine ( Table 4 ). 5HT concentrations were also noted to be increased in area postrema, brain stem, and intestine with significance of P < 0.01, P < 0.001, and P < 0.001, respectively, and did not affect the levels of others (DOPAC, HVA, 5HIAA, and NA) ( Table 4 ).

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