Long-primed germinal centres with enduring affinity maturation and clonal migration.

The difference in SHM in the long prime (week 29) versus 10 week prime was highly significant ( P < 0.0001 by Mann–Whitney, Fig. 4b ; P < 0.0009, Fig. 4c ), and the difference in median mutations between weeks 10 and 29 was as great as that between weeks 4 and 10, indicative of robust GC functionality continuing through to at least week 29 (Fig. 4a–c ).

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