Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography.

This change in density with activating Fab may be significant because the model in the literature for the monomeric state of E-cadherin has the Trp2 forming an intramolecular bond, filling the hydrophobic pocket in its own subunit, and the extrusion of the Trp2 leads to the intermolecular strand-swap dimer that underlies adhesive bond formation.

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