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Prescribing Patterns of Codeine and Alternative Medicines in Children in Europe.

Drug Saf · 2022 · PMC9492592 · PMID 36001288

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an increasing trendno p-value reported
No changes were visible in the three other countries immediately nor later post-second referral (only an increasing trend of opioid antitussives in Germany which remained extremely close zero use) (Figs. 5 , 6 , Tables 5 , 6 ).

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a decreasing trendno p-value reported
Results Overall Trends in Codeine Prescribing in Children Below 12 Years of Age A decreasing trend in the prevalence rate in children was visible in Spain and the UK prior to the first referral (from 4.63 to close to 0 and 0.26 to 0.15, respectively).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.