NADPH Oxidase Mediates Oxidative Stress and Ventricular Remodeling through SIRT3/FOXO3a Pathway in Diabetic Mice.

To determine the mitochondrial function in the three groups, we evaluated the expression of mitochondria-associated proteins of ventricular tissue and found that the expression levels of PGC1-α, Mn-SOD, TFAM, and MFN2 showed a decreasing trend in the diabetes group compared to the control group ( Figure 3 C–G).

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