Blood Eosinophils and Exhaled Nitric Oxide: Surrogate Biomarkers of Airway Eosinophilia in Stable COPD and Exacerbation.

The rationale for using FENO in the assessment and management of various respiratory diseases is based on two key factors: first, there is a highly significant relationship between FENO levels and the extent of eosinophilia in airway specimens such as induced sputum, bronchoalveolar lavage and biopsy materials; second, there is an equally important relationship between eosinophilic airway inflammation and steroid responsiveness [ 40 ].

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