Quetiapine Ameliorates MIA-Induced Impairment of Sensorimotor Gating: Focus on Neuron-Microglia Communication and the Inflammatory Response in the Frontal Cortex of Adult Offspring of Wistar Rats.

Cells · 2022 · PMC9496681 · PMID 36139363

Europe PMC DOI

hedged sentences

0.0762

closest p · 1.5× alpha

0.0762

boldest claim

The sentences

an increasing trendp = 0.0762so close (0.05 < p ≤ 0.1)

2.95 ± 0.65 LPS + vehicle, F (1,19) = 12.93, p = 0.0202) and an increasing trend in the mRNA expression of Cx3cr1 (1.01 ± 0.04 control + vehicle vs. 1.51 ± 0.23 LPS + vehicle, F (1,32) = 3.97, p = 0.0762) in the frontal cortices of the rats prenatally subjected to LPS.

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a positive trendno p-value reported

Chronic treatment with antipsychotics did not significantly affect these modifications, although quetiapine showed a positive trend for an increase in Cx3cl1 - Cx3cr1 expression in the hippocampus, in which deficits in neurotransmission (e.g., GABAergic) are particularly strongly expressed in male offspring in the MIA model [ 67 ].

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