Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma.

Nat Med · 2022 · PMC9499856 · PMID 36038629

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a positive trendno p-value reported

The evolution of TME gene expression patterns was vastly different in non-responders, where no increase in immune-related genes was observed, except for a positive trend in two pro-inflammatory chemokines (CXCL10 and CXCL11) that was consistent across FF and FFPE sample sets (Extended Data Fig. 2d,e ) and likely modulated by chemo-conditioning 27 .

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