A report on the potential of Rac1/pSTAT3 protein levels in T lymphocytes to assess the pharmacodynamic effect of thiopurine therapy in Inflammatory Bowel Disease patients.

Sci Rep · 2022 · PMC9500076 · PMID 36138194

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0.0180

closest p · 0.4× alpha

0.0180

boldest claim

The sentences

borderline significancep = 0.018actually significant

pSTAT3 corrected for Rac1 Rac1-corrected pSTAT3 protein levels in IBD patients groups on thiopurine monotherapy AZA/MP (median 0.66 AU) or TG (median 0.68 AU) were reduced compared to IBD patients with active disease with borderline significance (median 1.33 AU) (p = 0.018 and p = 0.016, respectively) (Fig. 4 C).

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