Investigation of Alogliptin-Loaded In Situ Gel Implants by 2³ Factorial Design with Glycemic Assessment in Rats.

In addition, the interaction plot of variables (B and C) displayed the highly significant impact of changing the PLGA amount from its lowest to its highest level on the burst release as clarified by the remarkable distance between the upper black line and lower red line, where the former line expressed the lowest level of factor C and the latter one expressed the highest level of such factor ( Figure 4 d).

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When the t value was found between the two limit lines, the effect was likely to be significant.

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