Exploring the mechanism of action of Sanzi formula in intervening colorectal adenoma by targeting intestinal flora and intestinal metabolism.

Besides, the expression of Deoxycytidine , N-Acetyl-D-Galactosamine , and Phytosphingosine , all of which have some degree of toxicity and mucosal irritation, was elevated in the CRA model, while the high expression of these metabolites is considered to be closely tied with colorectal cancer ( Goedert et al., 2014 ; Brown et al., 2016 ; Sun et al., 2021 ), and all showed a decreasing trend in expression after treatment with SZF.

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