Updates and Original Case Studies Focused on the NMR-Linked Metabolomics Analysis of Human Oral Fluids Part II: Applications to the Diagnosis and Prognostic Monitoring of Oral and Systemic Cancers.

However, overall, the AUROC value for this model was only 0.66 (95% CI 0.52–0.81), so it was only barely statistically significant ( p = 0.036).

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Qualitative pathway topological analysis ( MetaboAnalyst 5.0, https://www.metaboanalyst.ca , (accessed on 19 August 2022), University of Alberta, Edmonton, Canada) performed on each of these three pools of biomarkers by the authors of the current study revealed that only the first set tested with 14 named biomolecules and the very highest level of significance ( p < 0.001) implicated only the branched-chain amino acid (BCAA) catabolism and histidine metabolism pathways as being perturbed in oral cancer patients; however, although the raw p values for these pathways were highly significant (4.76 and 8.46 × 10 −3 , respectively), they did not remain so following FDR correction ( p = 0.13 and 0.18, respectively).

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