highly significantP <0.0001
Lastly, analysis of the relative usage of pAs in 182 genes that displayed significant modulation of at least two alternative pAs ( Supplementary Table S7 ) highlighted a highly significant negative correlation between the abundance of the two APA isoforms for most genes (92.85%; r = –0.8936, P <0.0001, Pearson correlation; Figure 2F ), thus confirming the effect on transcript lengthening induced by HT.