Early antibiotic therapy is associated with a lower probability of successful liberation from mechanical ventilation in patients with severe acute exacerbation of chronic obstructive pulmonary disease.

Ann Intensive Care · 2022 · PMC9509513 · PMID 36153438

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a decreasing trendno p-value reported

Furthermore, the latter study reported an even greater decrease over time in the use of empiric antibiotic therapy in ICU patients admitted with AECOPD between 2000 and 2012 (from 68 to 33%) [ 30 ], along with a decreasing trend in mortality (from 12.9% in 2000 to 6.7% in 2012).

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