Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication.

However, by 36 hpi, a marked increase in apoptosis and cell death was observed in infected rictor knockdown cells, both of which were highly significant (4 A , D , and E , p < 0.001 for activated caspase 3 level, p < 0.01 for cell viability).

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