Reduction in gut-derived MUFAs via intestinal stearoyl-CoA desaturase 1 deletion drives susceptibility to NAFLD and hepatocarcinoma.

To determine whether hepatic TG accumulation would be a consequence of increased lipid absorption, we performed an oral gavage with TGs and observed a nonsignificant trend toward a higher absorption in i Scd1 −/− versus i Scd1 +/+ mice (Figure 2D ).

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