Patient-reported outcomes in a pilot clinical trial of twice-weekly hemodialysis start with adjuvant pharmacotherapy and transition to thrice-weekly hemodialysis vs conventional hemodialysis.

After adjustment for baseline covariate differences, the least square mean change (standard error [SE]) in DSI was borderline significant in the incremental group (− 9.7 [4.8], P = 0.05) and it remained strongly significant in the conventional group (− 13.8 [5.0], P = 0.009).

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