Single-cell transcriptome profiling of the human endometrium of patients with recurrent implantation failure.

Importantly, gene expression (e.g, COL6A1 , FBLN1 , and FN1 ) in focal adhesion, embryo implantation, ECM remodeling, blood vessel remodeling peaked during FIB2 differentiation, and a decreasing trend was then observed in the FIB3 differentiation, which was characterized by high expression of histone methylation, positive regulation of cell killing, necrotic cell death, chromatin remodeling and lysine degradation-related genes (e.g., JMJD1C , KMT2C , ELN , and REV3L ) ( Figure 3 D , Figure S7 ).

also in 47,180 other papers