Oral Lesions Associated with COVID-19 and the Participation of the Buccal Cavity as a Key Player for Establishment of Immunity against SARS-CoV-2.

Recent research has confirmed that the risk of several adverse events in patients with COVID-19 is considerably higher in patients with periodontitis [ 128 , 129 ]; this resulted from a multivariate logistic regression model in which they found that the associations between patients who had COVID-19 and patients who had periodontitis adjusted for possible confounders such as gender, age, and smoking, as well as comorbidities they might suffer from; after this adjustment, periodontitis undoubtedly had a highly significant impact on the progression and evolution of SARS-CoV-2 infection, having also highly significant associations with health complications caused by COVID-19 (OR = 3.67, 95% CI: 1.46–9.27), ICU admission (OR = 3.54, 95% CI: 1.39–9.05), death (OR = 8.81, 95% CI: 1.00–77.7), and need for mechanical ventilation (OR = 4.57, 95% CI: 1.19–17.4) when compared to patients with mild periodontal disease or healthy periodontium [ 14 ].

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