Interestingly, a recent longitudinal study in a small group of PD patients 20 demonstrated highly significant correlations between changes over time in putaminal dopamine transporter density and the changes in FC of the posterior putamen with midbrain, thalamus, supplementary motor area and sensorimotor cortex.
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Functional connectivity of the cortico-subcortical sensorimotor loop is modulated by the severity of nigrostriatal dopaminergic denervation in Parkinson's Disease.
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