pT3 colorectal cancer revisited: a multicentric study on the histological depth of invasion in more than 1000 pT3 carcinomas-proposal for a new pT3a/pT3b subclassification.

Impact of the proposed pT3a/pT3b substratification on survival parameters within pT3 CRC in the training cohort and in the validation cohorts We observed highly significant differences regarding all survival parameters between patients with pT3a and pT3b CRCs in all cohorts (DFS: P < 0.001 all cohorts, OS: P < 0.001 training cohort/validation cohort 2, P = 0.002 validation cohort 1, DSS: see below).

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