A cytokine/PTX3 prognostic index as a predictor of mortality in sepsis.

Front Immunol · 2022 · PMC9521428 · PMID 36189302

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highly significantno p-value reported

Additionally, when PTX3, urea levels and age were left unchanged, there was a highly significant interaction (positive synergistic effect) between IL-6 and IL-18, meaning there was a non-linear association between these two variables and 90-days mortality.

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an increasing trendno p-value reported

Although an increasing trend was seen from non-sepsis to sepsis and shock patients, IL-18BP and IL-1R4 were not significantly associated with mortality, in contrast to what reported by others ( 93 , 96 – 98 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.