Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?

Chin Med J (Engl) · 2022 · PMC9521762 · PMID 35838408

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hedged sentences

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

marginal significanceP = 0.059so close (0.05 < p ≤ 0.1)

Loci rs11627387, rs1076991, and rs2236225 may have interactive effects on the IQ scores according to analyses of gene-gene interaction [Figure 4 ], where the association showed marginal significance ( F = 1.726, P = 0.059).

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borderline significantP = 0.059so close (0.05 < p ≤ 0.1)

There was an increment in IQ score in children carrying the G allele than in those with the A allele of rs11627387 in the HFG, and the association was borderline significant ( P = 0.059) [Figure 2 ].

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