This difference is highly significant ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$P=1.01\times 10^{-24}$$\end{document} P = 1.01 × 10 - 24 , binomial test; see “ Methods ” section for details), consistent with the expectation of lower saturation at WC than at UP sites, and therefore with the hypothesis that there is epistatic constraint to preserve the SARS-CoV-2 secondary structure.
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