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The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review.

Front Pharmacol · 2022 · PMC9525219 · PMID 36193419

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an increasing trendno p-value reported
The pharmacokinetic parameters of spinosin in ZJSP between the control group (NC) and insomnia model (IM) group were determined using the UPLC-MS method, and the results showed no significant differences between the two groups, but an increasing trend for CL and the decreasing trend for the AUC 0-t and AUC 0-∞ of spinosin in the IM group, which indicated the faster and poorer absorption of spinosin in the IM group ( Du et al., 2020 ).

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