Effect of hyperglycaemia in combination with moxifloxacin on cardiac repolarization in male and female patients with type I diabetes.

When added as a covariate to the primary model, the type of insulin regime was found to have an influence on the duration of QTcF (Table 4), although this did not quite reach significance ( F 2.35, p = 0.12).

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Moxifloxacin administration was borderline significant ( F value 2.18, p = 0.14) but with limited effect, and the interaction between glucose and moxifloxacin was also borderline significant ( p = 0.067) suggesting the effect of moxifloxacin in addition to glucose on the QTcF is additive, not exponential, reflected in the similar regression line slopes.

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Concentration-effect modelling (not shown) for JTp c J showed again a highly significant influence of glucose concentration on JTp c J prolongation ( F 54.59, p = < 0.0001) while the interaction of glucose and moxifloxacin neared but not quite reached significance ( p = 0.11).

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