Proposal of the French HIV Society on the CD4 threshold below which patients living with HIV who wish to be vaccinated against Monkeypox should receive a 3-dose regimen.

A two-dose regimen (W0, W4) when the CD4 count is lower than 200/mm 3 and/or <15 % of the CD4 count 3) For PLHIV with a CD4 count <500/mm 3 and pending further data, we recommend that the time between the first and second injection not be increased as the loss of immunogenicity may be significant. 4) For PLHIV with a CD4 count <50/mm 3 , the benefit of vaccination is unlikely because of a likely insufficient immune response.

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