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Lineage-specific positive selection on <i>ACE2</i> contributes to the genetic susceptibility of COVID-19.

Natl Sci Rev · 2022 · PMC9529360 · PMID 36199986

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a pronounced trendno p-value reported
Overall, there was a pronounced trend of increasing COVID-19 severity with an increased proportion of ACE2 -hg1 and decreased proportion of ACE2 -hg2 (Fig. 4 A).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.