Optimal Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention: A Focused Review on High Bleeding Risk.

Recent meta-analyses have revealed that DAPT durations of 6 months or less and even shorter durations of 3 months or less compared with 12 months or more are associated with a lower risk of bleeding, comparable efficacy regardless of ACS or CCS, and a decreasing trend of overall mortality 50) .

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The LEADERS FREE trial 19) and several other trials 18 , 20 , 21) were conducted to evaluate the efficacy of new DES, which are designed to be effective in HBR patients, given the clinical situations where a certain percentage of patients undergoing coronary stenting with DES have to discontinue DAPT due to bleeding complications, and this percentage shows an increasing trend with the increase in aging population with comorbidities.

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