An effect size less than 0.2 is considered a small effect, 0.3–0.7 is a medium effect indicating a trend for practical significance, and effect sizes of 0.8 and greater is considered large and practically significant ( Cohen, 1977 ). 3.
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Bio-behavioural changes in treatment-resistant socially isolated FSL rats show variable or improved response to combined fluoxetine-olanzapine versus olanzapine treatment.
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The latter showed a similar trend but failed to reach significance versus SD-SOC-SAL treated animals.