Methylprednisolone Inhibits Autophagy of Vascular Endothelial Cells in Rat Femoral Head Via PI3K/Akt/mTOR Pathway.

Orthop Surg · 2022 · PMC9531065 · PMID 36052745

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an overall trendno p-value reported

8 , the content of 6‐Keto‐PGF1 α in the control group did not change over time, while that in the hormone group showed an overall trend of increase over time, indicating that hormones could damage VEC and the damage would worsen over time.

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a decreasing trendno p-value reported

an increasing trendno p-value reported

The expressions of Beclin1 and MAP1LC3 in the hormone group showed a decreasing trend, while the expressions of PI3K, Akt and mTOR showed an increasing trend, indicating that the physiological autophagy level of VEC decreased with the passage of hormone action.

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