SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests.

Nat Genet · 2022 · PMC9534766 · PMID 36138231

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marginally significantno p-value reported

Due to multiple comparison burden, including lower MAF cutoffs can make marginally significant associations insignificant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.